FORSCHUNG

Publikationen

Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G.

Brief Report: Humoral and cellular immune responses to SARS-CoV-2 infection and vaccination in B cell depleted autoimmune patients.


Arthritis Rheumatol. 2021 Jul 1. doi: 10.1002/art.41914. Online ahead of print. PMID: 34196506.


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Simon D, Tascilar K, Fagni F, Krönke G, Kleyer A, Meder C, Atreya R, Leppkes M, Kremer AE, Ramming A, Pachowsky ML, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Berking C, Sticherling M, Neurath MF, Schett G.

SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases.


Ann Rheum Dis. 2021 May 6:annrheumdis-2021-220461.


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AUSWAHL

2021

  • Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G. Brief Report: Humoral and cellular immune responses to SARS-CoV-2 infection and vaccination in B cell depleted autoimmune patients. Arthritis Rheumatol. 2021 Jul 1. doi: 10.1002/art.41914. Online ahead of print. PMID: 34196506.

  • Simon D, Tascilar K, Fagni F, Krönke G, Kleyer A, Meder C, Atreya R, Leppkes M, Kremer AE, Ramming A, Pachowsky ML, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Berking C, Sticherling M, Neurath MF, Schett G. SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases. Ann Rheum Dis. 2021 May 6:annrheumdis-2021-220461. doi: 10.1136/annrheumdis-2021-220461. Epub ahead of print. PMID: 33958324; PMCID: PMC8103562.

  • 2020

  • Simon D, Tascilar K, Krönke G, Kleyer A, Zaiss MM, Heppt F, Meder C, Atreya R, Klenske E, Dietrich P, Abdullah A, Kliem T, Corte G, Morf H, Leppkes M, Kremer AE, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Maier C, Hueber AJ, Manger K, Manger B, Berking C, Tenbusch M, Überla K, Sticherling M, Neurath MF, Schett G. Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion. Nat Commun. 2020 Jul 24;11(1):3774. doi: 10.1038/s41467-020-17703-6. PMID: 32709909; PMCID: PMC7382482.

  • 2019

  • d'Oliveira I, Döltz S, Manger K, Hueber AJ. Handschmerzen, Muskelschmerzen und Lippenschwellung [Hand pain, muscle pain and swollen lips]. Z Rheumatol. 2019 Sep;78(7):656-659. German. doi: 10.1007/s00393-019-0679-7. PMID: 31359144.

  • Ham-Karim HA, Ebili HO, Manger K, Fadhil W, Ahmad NS, Richman SD, Ilyas M. Targeted Next-Generation Sequencing Validates the Use of Diagnostic Biopsies as a Suitable Alternative to Resection Material for Mutation Screening in Colorectal Cancer. Mol Diagn Ther. 2019 Jun;23(3):383-393. doi: 10.1007/s40291-019-00388-z. PMID: 30741375.

  • Hagen M, Englbrecht M, Haschka J, Reiser M, Kleyer A, Hueber A, Manger B, Figueiredo C, Cobra JF, Tony HP, Finzel S, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Lorenz HM, Nüsslein H, Alten R, Henes J, Krüger K, Schett G, Rech J. Cost-effective Tapering Algorithm in Patients with Rheumatoid Arthritis: Combination of Multibiomarker Disease Activity Score and Autoantibody Status. J Rheumatol. 2019 May;46(5):460-466. doi: 10.3899/jrheum.180028. Epub 2018 Dec 1. PMID: 30504510.

  • 2018

  • Manger K, von Streitberg U, Seitz G, Kleyer A, Manger B. Hard palate hyperpigmentation-a rare side effect of antimalarials. Arthritis Rheumatol. 2018 Jan;70(1):152. doi: 10.1002/art.40327. Epub 2017 Nov 28. PMID: 28941224.

  • 2017

  • Figueiredo CP, Bang H, Cobra JF, Englbrecht M, Hueber AJ, Haschka J, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nuesslein H, Alten R, Henes J, Krueger K, Rech J, Schett G. Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs. Ann Rheum Dis. 2017 Feb;76(2):399-407. doi: 10.1136/annrheumdis-2016-209297. Epub 2016 Jun 20. PMID: 27323772.

  • 2016

  • Rech J, Hueber AJ, Finzel S, Englbrecht M, Haschka J, Manger B, Kleyer A, Reiser M, Cobra JF, Figueiredo C, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nuesslein H, Alten R, Henes J, Krueger K, Schett G. Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment. Ann Rheum Dis. 2016 Sep;75(9):1637-44. doi: 10.1136/annrheumdis-2015-207900. Epub 2015 Oct 19. PMID: 26483255; PMCID: PMC5013080.

  • Haschka J, Englbrecht M, Hueber AJ, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt- Haendle M, Wendler J, Schuch F, Ronneberger M, Lorenz HM, Nuesslein H, Alten R, Demary W, Henes J, Schett G, Rech J. Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. Ann Rheum Dis. 2016 Jan;75(1):45-51. doi: 10.1136/annrheumdis-2014-206439. Epub 2015 Feb 6. PMID: 25660991.

  • 2014

  • Proft F, Steinbach S, Dechant C, Witt M, Reindl C, Schulz S, Vielhauer V, Hilge R, Laubender RP, Manger K, Nüsslein H, Wendler J, Schuch F, Schulze-Koops H, Grunke M. Gustatory and olfactory function in patients with granulomatosis with polyangiitis (Wegener's). Scand J Rheumatol. 2014;43(6):512-8. doi: 10.3109/03009742.2014.915056. Epub 2014 Sep 10. PMID: 25204208.

  • Richter JG, Häckel B, Manger K, Riechers E, Schmeding A, Thies W, Schneider M. Welche Faktoren bestimmen die direkten Krankheits-kosten bei Patienten mit Systemischem Lupus Erythe-matodes in Deutschland? - Subanalyse der LUCIE-Studie [What factors determine the direct medical costs of patients with systemic lupus erythematosus in Germany? Subanalysis of the LUCIE study]. Gesundheitswesen. 2014 Jan;76(1):41-3. German. doi: 10.1055/s-0033-1334935. Epub 2013 Mar 19. PMID: 23512471.

  • 2012

  • Lang VR, Englbrecht M, Rech J, Nüsslein H, Manger K, Schuch F, Tony HP, Fleck M, Manger B, Schett G, Zwerina J. Risk of infections in rheumatoid arthritis patients treated with tocilizumab. Rheumatology (Oxford). 2012 May;51(5):852-7. doi: 10.1093/rheumatology/ker223. Epub 2011 Aug 24. PMID: 21865281.

  • 2011

  • Manger B, Lindner A, Manger K, Wacker J, Schett G. Hypertrophe Osteoarthropathie. Marie-Bamberger-Syndrom [Hypertrophic osteoarthropathy. Bamberger-Marie disease]. Z Rheumatol. 2011 Sep;70(7):554-60. German. doi: 10.1007/s00393-011-0813-7. PMID: 21735289.

  • Lang VR, Englbrecht M, Rech J, Nüsslein H, Manger K, Schuch F, Tony HP, Fleck M, Manger B, Schett G, Zwerina J. Risk of infections in rheumatoid arthritis patients treated with tocilizumab. Rheumatology (Oxford). 2012 May;51(5):852-7. doi: 10.1093/rheumatology/ker223. Epub 2011 Aug 24. PMID: 21865281.

  • 2010

  • Rech J, Ronneberger M, Englbrecht M, Finzel S, Katzenbeisser J, Manger K, Manger B, Schett G. Successful treatment of adult-onset Still's disease refractory to TNF and IL-1 blockade by IL-6 receptor blockade. Ann Rheum Dis. 2011 Feb;70(2):390-2. doi: 10.1136/ard.2010.129403. Epub 2010 Jul 22. PMID: 20650873.

  • Fürnrohr BG, Wach S, Kelly JA, Haslbeck M, Weber CK, Stach CM, Hueber AJ, Graef D, Spriewald BM, Manger K, Herrmann M, Kaufman KM, Frank SG, Goodmon E, James JA, Schett G, Winkler TH, Harley JB, Voll RE. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. Ann Rheum Dis. 2010 Nov;69(11):1983-9. doi: 10.1136/ard.2009.122630. Epub 2010 May 24. PMID: 20498198; PMCID: PMC3002760.

  • Nossent J, Kiss E, Rozman B, Pokorny G, Vlachoyiannopoulos P, Olesinska M, Marchesoni A, Mosca M, Påi S, Manger K, Schneider M, Nielsen H, van Vollenhoven R, Swaak T. Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus. Lupus. 2010 Jul;19(8):949-56. doi: 10.1177/0961203310366572. Epub 2010 Apr 7. PMID: 20375124.

  • 2009

  • Manger K, Nüsslein H, Schett G, Manger B. Rare monogenetic syndromes in rheumatology practice. Clin Rheumatol. 2009 Jun;28(6):623-30. doi: 10.1007/s10067-009-1117-z. Epub 2009 Feb 18. PMID: 19224127.

  • 2007

  • Chen JA, Meister S, Urbonaviciute V, Rödel F, Wilhelm S, Kalden JR, Manger K, Voll RE. Sensitive detection of plasma/serum DNA in patients with systemic lupus erythematosus. Autoimmunity. 2007 Jun;40(4):307-10. doi: 10.1080/08916930701356317. PMID: 17516216.

  • Metzler C, Miehle N, Manger K, Iking-Konert C, de Groot K, Hellmich B, Gross WL, Reinhold-Keller E; German Network of Rheumatic Diseases. Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis. Rheumatology (Oxford). 2007 Jul;46(7):1087-91. doi: 10.1093/rheumatology/kem029. Epub 2007 May 22. PMID: 17519271.

  • Ott HW, Mattle V, Hadziomerovic D, Licht P, Döinghaus K, Rubbert A, Manger K, Manger B, Kalden J, Wildt L. Treatment of hereditary angioneurotic oedema (HANE) with tibolone. Clin Endocrinol (Oxf). 2007 Feb;66(2):180-4. doi: 10.1111/j.1365-2265.2006.02704.x. PMID: 17223985.

  • Beier F, Balabanov S, Amberger CC, Hartmann U, Manger K, Dietz K, Kötter I, Brummendorf TH. Telomere length analysis in monocytes and lymphocytes from patients with systemic lupus erythematosus using multi-color flow-FISH. Lupus. 2007;16(12):955-62. doi: 10.1177/0961203307084299. PMID: 18042589.

  • Ringwald J, Buettner S, Zimmermann R, Weisbach V, Strasser E, Eckstein R, Eckel K, Manger K. Thrombin-activatable fibrinolysis inhibitor and activated factor XII in patients with systemic lupus erythematosus. Thromb Res. 2007;119(1):129-31. doi: 10.1016/j.thromres.2006.01.002. Epub 2006 Feb 8. PMID: 16466780.

  • 2006

  • Momot T, Ahmadi-Simab K, Gause A, Gross WL, Gromnica-Ihle E, Peter HH, Manger K, Zeidler H, Schmidt RE, Witte T. Lack of association of mannose binding lectin variant alleles with systemic lupus erythematosus. Ann Rheum Dis. 2006 Feb;65(2):278-9. doi: 10.1136/ard.2005.042929. PMID: 16410540; PMCID: PMC1798033.

  • 2005

  • Manger K, Wildt L, Kalden JR, Manger B. Prevention of gonadal toxicity and preservation of gonadal function and fertility in young women with systemic lupus erythematosus treated by cyclophosphamide: the PREGO-Study. Autoimmun Rev. 2006 Apr;5(4):269-72. doi: 10.1016/j.autrev.2005.10.001. Epub 2005 Oct 27. PMID: 16697968.

  • Unger L, Kayser M, Enderlein M, Manger K, Nüsslein H. Glucocorticoidtherapie bei Kollagenosen [Glucocorticoid therapy in collagen diseases diseases]. Z Rheumatol. 2005 Apr;64(3):162-9. German. doi: 10.1007/s00393-005-0721-9. PMID: 15868333.

  • 2004

  • Manger K, Dechant C, Kalden JR, Manger B. Clinical images: Periarticular inflammation in rapidly developing Jaccoud's arthropathy. Arthritis Rheum. 2004 May;50(5):1700. doi: 10.1002/art.20262. PMID: 15146452.

  • 2003

  • Manger K, Kusus M, Forster C, Ropers D, Daniel WG, Kalden JR, Achenbach S, Manger B. Factors associated with coronary artery calcification in young female patients with SLE. Ann Rheum Dis. 2003 Sep;62(9):846-50. doi: 10.1136/ard.62.9.846. PMID: 12922957; PMCID: PMC1754656.

  • Karassa FB, Bijl M, Davies KA, Kallenberg CG, Khamashta MA, Manger K, Michel M, Piette JC, Salmon JE, Song YW, Tsuchiya N, Yoo DH, Ioannidis JP. Role of the Fcgamma receptor IIA polymorphism in the antiphospholipid syndrome: an international meta-analysis. Arthritis Rheum. 2003 Jul;48(7):1930-8. doi: 10.1002/art.11059. PMID: 12847687.

  • Manger K, Manger B. Gibt es eine Indikation für TNF alpha-Antagonisten bei Kollagenosen? [TNF alpha-antagonists in collagen vascular disease]. Z Rheumatol. 2003 Jun;62(3):240-5. German. doi: 10.1007/s00393-003-0530-y. PMID: 12827400.

  • Hay FR, Mead A, Manger K, Wilson FJ. One-step analysis of seed storage data and the longevity of Arabidopsis thaliana seeds. J Exp Bot. 2003 Mar;54(384):993-1011. doi: 10.1093/jxb/erg103. PMID: 12598570.

  • 2002

  • Manger K, Manger B, Repp R, Geisselbrecht M, Geiger A, Pfahlberg A, Harrer T, Kalden JR. Definition of risk factors for death, end stage renal disease, and thromboembolic events in a monocentric cohort of 338 patients with systemic lupus erythematosus. Ann Rheum Dis. 2002 Dec;61(12):1065-70. doi: 10.1136/ard.61.12.1065. PMID: 12429536; PMCID: PMC1753955.

  • Manger K, Manger B. Konsequenzen der verbesserten Prognose des SLE [Sequelae of improved prognosis of SLE]. Z Rheumatol. 2002 Oct;61(5):532-3. German. doi: 10.1007/s00393-002-0416-4. PMID: 12399880.

  • Manger K, Repp R, Jansen M, Geisselbrecht M, Wassmuth R, Westerdaal NA, Pfahlberg A, Manger B, Kalden JR, van de Winkel JG. Fcgamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms. Ann Rheum Dis. 2002 Sep;61(9):786-92. doi: 10.1136/ard.61.9.786. PMID: 12176802; PMCID: PMC1754233.

  • 2001

  • Swaak AJ, van den Brink HG, Smeenk RJ, Manger K, Kalden JR, Tosi S, Domljan Z, Rozman B, Logar D, Pokorny G, Kovacs L, Kovacs A, Vlachoyiannopoulos PG, Moutsopoulos HM, Chwalinska-Sadowska H, Kiss E, Cikes N, Anic B, Schneider M, Fischer R, Bombardieri S, Mosca M, Graninger W, Smolen JS. Systemic lupus erythematosus. Disease outcome in patients with a disease duration of at least 10 years: second evaluation. Lupus. 2001;10(1):51-8. doi: 10.1191/096120301666282314. PMID: 11243510.

  • Swaak AJ, van de Brink H, Smeenk RJ, Manger K, Kalden JR, Tosi S, Marchesoni A, Domljan Z, Rozman B, Logar D, Pokorny G, Kovacs L, Kovacs A, Vlachoyiannopoulos PG, Moutsopoulos HM, Chwalinska-Sadowska H, Dratwianka B, Kiss E, Cikes N, Anic B, Schneider M, Fischer R, Bombardieri S, Mosca M, Graninger W, Smolen JS; Study group on incomplete SLE and SLE with disease duration longer than 10 years. Incomplete lupus erythematosus: results of a multicentre study under the supervision of the EULAR Standing Committee on International Clinical Studies Including Therapeutic Trials (ESCISIT). Rheumatology (Oxford). 2001 Jan;40(1):89-94. doi: 10.1093/rheumatology/40.1.89. PMID: 11157147.

  • 2000

  • Hundt M, Manger K, Dörner T, Grimbacher B, Kalden P, Rascu A, Weber D, Burmester GR, Peter HH, Kalden JR, Schmidt RE. Treatment of acute exacerbation of systemic lupus erythematosus with high-dose intravenous immunoglobulin. Rheumatology (Oxford). 2000 Nov;39(11):1301-2. doi: 10.1093/rheumatology/39.11.1301. PMID: 11085821.

  • 1999

  • Swaak AJ, van den Brink HG, Smeenk RJ, Manger K, Kalden JR, Tosi S, Marchesoni A, Domljan Z, Rozman B, Logar D, Pokorny G, Kovacs L, Kovacs A, Vlachoyiannopoulos PG, Moutsopoulos HM, Chwalinska-Sadowska H, Dratwianka B, Kiss E, Cikes N, Branimir A, Schneider M, Fischer R, Bombardieri S, Mosca M, Smolen JS, et al. Systemic lupus erythematosus: clinical features in patients with a disease duration of over 10 years, first evaluation. Rheumatology (Oxford). 1999 Oct;38(10):953-8. doi: 10.1093/rheumatology/38.10.953. PMID: 10534545.

  • 1998

  • Manger K, Repp R, Spriewald BM, Rascu A, Geiger A, Wassmuth R, Westerdaal NA, Wentz B, Manger B, Kalden JR, van de Winkel JG. Fcgamma receptor IIa polymorphism in Caucasian patients with systemic lupus erythematosus: association with clinical symptoms. Arthritis Rheum. 1998 Jul;41(7):1181-9. doi: 10.1002/1529-0131(199807)41:7<1181::AID-ART6>3.0.CO;2-C. PMID: 9663473.

  • Schwab J, Schwab M, Manger K, Manger B, Wünsch PH, Gottwik M. Churg-Strauss- Syndrom mit rechtsventrikulärem Tumor [Churg-Strauss syndrome with right ventricular tumor]. Dtsch Med Wochenschr. 1998 Apr 17;123(16):487-92. German. doi: 10.1055/s-2007-1023999. PMID: 9589022.

  • Manger K, Kalden JR. Gastritis und Thoraxschmerzen. Churg-Strauss vasculitis] [Gastritis and thoracic pain. Churg-Strauss vasculitis]. Med Klin (Munich). 1998 Mar 15;93(3):190. German. doi: 10.1007/BF03044838. PMID: 9564168.

  • 1996

  • Rascu A, Manger K, Kraetsch HG, Kalden JR, Manger B. Osteonecrosis in systemic lupus erythematosus, steroid-induced or a lupus-dependent manifestation? Lupus. 1996 Aug;5(4):323-7. doi: 10.1177/096120339600500414. PMID: 8869906.

  • Manger K, Kalden JR, Manger B. Cyclosporin A in the treatment of systemic lupus erythematosus: results of an open clinical study. Br J Rheumatol. 1996 Jul;35(7):669-75. doi: 10.1093/rheumatology/35.7.669. PMID: 8670602.

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